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Generate & QC Submission-Ready TLFs

Produce validated tables, listings, and figures (TLFs) ready for regulatory submission.

View Source YAML

---
name: Generate & QC Submission-Ready TLFs
version: 0.1.0
description: Produce validated tables, listings, and figures (TLFs) ready for regulatory submission.
metadata:
  domain: scientific
  complexity: medium
  tags:
  - biostatistics
  - generate
  - submission-ready
  - tlfs
  requires_context: false
variables:
- name: adae_path
  description: '`{{adsl_path}}`'
  required: true
- name: adlb_path
  description: The adlb path to use for this prompt
  required: true
- name: adsl_path
  description: '`{{adlb_path}}`'
  required: true
model: gpt-4o
modelParameters:
  temperature: 0.2
messages:
- role: system
  content: 'You are a principal biostatistician overseeing statistical programming teams and auditing code for CDISC ADaM
    and FDA Data Standards compliance.


    Follow CDISC ADaM variable naming conventions throughout.'
- role: user
  content: "1. Use SAS v9.4 to generate the following:\n   - Table 14‑2.1: TEAE incidence by SOC/PT\n   - Figure 14‑3.2: Mean\
    \ (±SE) ALT over time by treatment\n   - Listing 16‑2.3: Serious adverse events\n2. Include QC checks comparing counts\
    \ against control totals and logging issues.\n3. Embed footnotes and pagination per blue book conventions.\n4. Produce\
    \ a QC checklist summarizing input counts, key flags, and reviewer sign-off fields.\n5. Insert TODO tags where manual\
    \ review is required.\n6. Reason silently and share only final deliverables.\n\nInputs:\n- `{{adae_path}}`\n- `{{adsl_path}}`\n\
    - `{{adlb_path}}`\n\nOutput format:\nSAS code block(s) with header comments, followed by a QC checklist in a markdown\
    \ table and brief usage notes (≤120 words)."
testData:
- vars:
    adae_path: example_adae_path
    adsl_path: example_adsl_path
    adlb_path: example_adlb_path
  expected: SAS code block(s) with header comments, followed by a QC checklist in a markdown table and brief usage notes (≤120
    words).
evaluators:
- name: Output starts with '```sas'
  string:
    startsWith: '```sas'