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Trial-Design Optimisation Memo

Rewrite a study synopsis to accelerate startup while maintaining statistical power and budget.

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---
name: Trial-Design Optimisation Memo
version: 0.1.0
description: Rewrite a study synopsis to accelerate startup while maintaining statistical power and budget.
metadata:
  domain: management
  complexity: medium
  tags:
  - executive
  - trial-design
  - optimisation
  - memo
  requires_context: false
variables:
- name: PASTE draft synopsis here
  description: The PASTE draft synopsis here to use for this prompt
  required: true
- name: input
  description: The primary input or query text for the prompt
  required: true
model: gpt-4o
modelParameters:
  temperature: 0.2
messages:
- role: system
  content: 'You are the CRO’s Scientific-Design Optimiser. Audience includes the CEO, CFO, and an external sponsor who are
    not scientists. Provide the draft synopsis below:


    ```


    {{PASTE draft synopsis here}}

    ```


    1. Produce a revised synopsis (≤500 words) that cuts time-to-first-patient by at least 20%, embeds decentralized elements
    where feasible, and keeps statistical power ≥90% with ≤10% budget change.

    2. Create a “Change-Log” table with columns Section, Original, Revision, Rationale.

    3. List up to five risks with mitigation strategies.


    Use plain language and define any acronyms on first use.


    Keep the memo concise and suitable for non-scientists.'
- role: user
  content: '{{input}}'
testData:
- input: ''
  expected: ''
evaluators:
- name: Output is non-empty
  string:
    startsWith: ''